MetaCyc Pathway: glycine betaine degradation III in Enterobacter sp. TBS_079

MetaCyc Pathway: glycine betaine degradation III in Enterobacter sp. TBS_079

glycine betaine + NADH + dioxygen + H⁺→N,N-dimethylglycine + formaldehyde + NAD⁺ + H₂O (EC 1.14.13.251)

No genes

N,N-dimethylglycine + 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O→sarcosine + formaldehyde + 2 H⁺ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.5.7.3)

No genes

sarcosine + 2 an oxidized ferredoxin [iron-sulfur] cluster + H₂O→glycine + formaldehyde + 2 H⁺ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.5.7.3)

No genes

Glycine hydroxymethyltransferase (in reverse):
glycine + a 5,10-methylenetetrahydrofolate + H₂O→L-serine + a tetrahydrofolate (EC 2.1.2.1)

L-serine ammonia-lyase:
L-serine→2-aminoprop-2-enoate + H₂O (EC 4.3.1.17)

Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)

2-iminopropanoate + H₂O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)

Links:

Pathway details at MetaCyc
Fitness data for 7 genes
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All MetaCyc pathways for Enterobacter sp. TBS_079

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information