MetaCyc Pathway: TCA cycle VI (Helicobacter) in Escherichia coli Nissle 1917

Add experiment(s):


2-oxoglutarate synthase:
2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
3-oxoacid CoA-transferase:
succinyl-CoA + acetoacetate→succinate + acetoacetyl-CoA (EC 2.8.3.5)
No genes
Succinate dehydrogenase (ubiquinone) (in reverse):
succinate[in] + a menaquinone→fumarate[in] + a menaquinol (EC 1.3.5.1)
ECOLIN_RS24115
ECOLIN_RS24120
ECOLIN_RS24135
ECOLIN_RS24140
ECOLIN_RS24145
ECOLIN_RS24150
ECOLIN_RS26280
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
ECOLIN_RS08995
ECOLIN_RS09000
ECOLIN_RS09370
ECOLIN_RS16300
ECOLIN_RS23850
(S)-malate + a menaquinone→oxaloacetate + a menaquinol (EC 1.1.5.4)
ECOLIN_RS12910
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
ECOLIN_RS03835
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
ECOLIN_RS00660
ECOLIN_RS04105
ECOLIN_RS07705
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
ECOLIN_RS00660
ECOLIN_RS04105
ECOLIN_RS07705
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
ECOLIN_RS06640

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information