MetaCyc Pathway: pentose phosphate pathway in Escherichia coli Nissle 1917

Glucose-6-phosphate dehydrogenase: D-glucopyranose 6-phosphate + NADP+→6-phospho D-glucono-1,5-lactone + NADPH + H+ (EC 1.1.1.49)

ECOLIN_RS10315

6-phosphogluconolactonase: 6-phospho D-glucono-1,5-lactone + H2O→D-gluconate 6-phosphate + H+ (EC 3.1.1.31)

ECOLIN_RS04085

Phosphogluconate dehydrogenase (decarboxylating): D-gluconate 6-phosphate + NADP+→D-ribulose 5-phosphate + CO2 + NADPH (EC 1.1.1.44)

ECOLIN_RS11990

Ribose-5-phosphate isomerase (in reverse): D-ribulose 5-phosphate→D-ribose 5-phosphate (EC 5.3.1.6)

ECOLIN_RS16215

ECOLIN_RS23690

Ribulose-phosphate 3-epimerase: D-ribulose 5-phosphate→D-xylulose 5-phosphate (EC 5.1.3.1)

ECOLIN_RS19345

ECOLIN_RS23665

ECOLIN_RS26950

Transketolase (in reverse): D-ribose 5-phosphate + D-xylulose 5-phosphate→D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (EC 2.2.1.1)

ECOLIN_RS14065

ECOLIN_RS16330

ECOLIN_RS22015

Transaldolase: D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate→D-erythrose 4-phosphate + β-D-fructofuranose 6-phosphate (EC 2.2.1.2)

ECOLIN_RS00045

ECOLIN_RS04390

ECOLIN_RS14060

ECOLIN_RS22790

Transketolase: D-erythrose 4-phosphate + D-xylulose 5-phosphate→β-D-fructofuranose 6-phosphate + D-glyceraldehyde 3-phosphate (EC 2.2.1.1)

ECOLIN_RS14065

ECOLIN_RS16330

ECOLIN_RS22015

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information