MetaCyc Pathway: pyruvate fermentation to propanoate I in Escherichia coli Nissle 1917

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Methylmalonyl-CoA carboxytransferase:
(S)-methylmalonyl-CoA + pyruvate→oxaloacetate + propanoyl-CoA (EC 2.1.3.1)
No genes
Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
ECOLIN_RS04265
ECOLIN_RS08525
ECOLIN_RS17375
ECOLIN_RS18555
ECOLIN_RS23455
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
ECOLIN_RS08995
ECOLIN_RS09000
ECOLIN_RS09370
ECOLIN_RS16300
ECOLIN_RS23850
Succinate dehydrogenase (ubiquinone):
fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
ECOLIN_RS24115
ECOLIN_RS24120
ECOLIN_RS24135
ECOLIN_RS24140
ECOLIN_RS24145
ECOLIN_RS24150
ECOLIN_RS26280
propanoyl-CoA + succinate→succinyl-CoA + propanoate (EC 2.8.3.27)
No genes
Methylmalonyl-CoA mutase (in reverse):
succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2)
ECOLIN_RS16230
Methylmalonyl-CoA epimerase:
(R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information