MetaCyc Pathway: L-arginine biosynthesis II (acetyl cycle) in Desulfovibrio vulgaris Hildenborough JW710

MetaCyc Pathway: L-arginine biosynthesis II (acetyl cycle) in Desulfovibrio vulgaris Hildenborough JW710

Glutamate--ammonia ligase:
L-glutamate + ammonium + ATP→L-glutamine + ADP + H⁺ + phosphate (EC 6.3.1.2)

DVU1258 (glnN)

DVU3392 (glnA)

Amino-acid N-acetyltransferase:
L-glutamate + acetyl-CoA→N-acetyl-L-glutamate + coenzyme A + H⁺ (EC 2.3.1.1)

DVU0823 (argJ)

Acetylglutamate kinase:
N-acetyl-L-glutamate + ATP→N-acetylglutamyl-phosphate + ADP (EC 2.7.2.8)

DVU1466 (argB)

Carbamoyl-phosphate synthase (glutamine-hydrolyzing):
L-glutamine + 2 ATP + hydrogen carbonate + H₂O→L-glutamate + carbamoyl phosphate + 2 ADP + 2 H⁺ + phosphate (EC 6.3.5.5)

DVU3113 (carA)

DVU0162 (carB)

N-acetyl-gamma-glutamyl-phosphate reductase (in reverse):
N-acetylglutamyl-phosphate + NADPH + H⁺→N-acetyl-L-glutamate 5-semialdehyde + NADP⁺ + phosphate (EC 1.2.1.38)

DVU0492 (argC)

Ornithine carbamoyltransferase:
carbamoyl phosphate + L-ornithine→L-citrulline + H⁺ + phosphate (EC 2.1.3.3)

DVU1096 (argF)

Acetylornithine transaminase (in reverse):
N-acetyl-L-glutamate 5-semialdehyde + L-glutamate→N-acetyl-L-ornithine + 2-oxoglutarate (EC 2.6.1.11)

DVU2347 (argD)

Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H⁺ (EC 6.3.4.5)

DVU1095 (argG)

Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)

DVU1094 (argH)

Glutamate N-acetyltransferase:
L-glutamate + N-acetyl-L-ornithine→N-acetyl-L-glutamate + L-ornithine (EC 2.3.1.35)

DVU0823 (argJ)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information