MetaCyc Pathway: valproate β-oxidation in Caulobacter crescentus NA1000

Add experiment(s):


Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
CCNA_00006
CCNA_00074
CCNA_00358
CCNA_00401
CCNA_00996
CCNA_01414
CCNA_01794
CCNA_01890
CCNA_01891
CCNA_01927
CCNA_02484
CCNA_02658
CCNA_03180
CCNA_03293
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
CCNA_00074
CCNA_01890
CCNA_03293
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
CCNA_00075
CCNA_00266
CCNA_00544
CCNA_00820
CCNA_00938
CCNA_01168
CCNA_01499
CCNA_02490
CCNA_03209
CCNA_03575
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
No genes
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
CCNA_00074
CCNA_01890
CCNA_03293
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
CCNA_00075
CCNA_00266
CCNA_00544
CCNA_00820
CCNA_00938
CCNA_01168
CCNA_01499
CCNA_02045
CCNA_02490
CCNA_03209
CCNA_03575

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information