MetaCyc Pathway: adipate biosynthesis in Ralstonia sp. UNC404CL21Col

3-oxoadipyl-CoA thiolase: acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A (EC 2.3.1.174)

ABZR87_RS15790

3-hydroxyacyl-CoA dehydrogenase (in reverse): 3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+ (EC 1.1.1.35)

ABZR87_RS00745

ABZR87_RS07480

ABZR87_RS12585

ABZR87_RS14655

ABZR87_RS23345

Enoyl-CoA hydratase: (3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O (EC 4.2.1.17)

ABZR87_RS02095

ABZR87_RS02100

ABZR87_RS06190

ABZR87_RS06470

ABZR87_RS07480

ABZR87_RS07495

ABZR87_RS11295

ABZR87_RS12585

ABZR87_RS14655

ABZR87_RS14660

ABZR87_RS16545

ABZR87_RS16935

ABZR87_RS17480

ABZR87_RS17485

ABZR87_RS20520

ABZR87_RS20900

ABZR87_RS21810

ABZR87_RS23090

ABZR87_RS23345

(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+

No genes

Succinate--CoA ligase (ADP-forming) (in reverse): adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A (EC 6.2.1.5)

ABZR87_RS07980

ABZR87_RS07985

ABZR87_RS15795

ABZR87_RS15800

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information