MetaCyc Pathway: fatty acid salvage in Ralstonia sp. UNC404CL21Col

MetaCyc Pathway: fatty acid salvage in Ralstonia sp. UNC404CL21Col

Butyrate--CoA ligase:
decanoate + ATP + coenzyme A→decanoyl-CoA + AMP + diphosphate (EC 6.2.1.2; 6.2.1.3)

decanoyl-CoA + an oxidized electron-transfer flavoprotein + H⁺→(2E)-dec-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)

Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-dec-2-enoyl-CoA + H₂O→(S)-3-hydroxydecanoyl-CoA (EC 4.2.1.74)

3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxydecanoyl-CoA + NAD⁺→3-oxodecanoyl-CoA + NADH + H⁺ (EC 1.1.1.35)

Acetyl-CoA C-acyltransferase (in reverse):
3-oxodecanoyl-CoA + coenzyme A→octanoyl-CoA + acetyl-CoA (EC 2.3.1.16)

octanoyl-CoA + a malonyl-[acp] + H⁺→a 3-oxodecanoyl-[acp] + CO₂ + coenzyme A (EC 2.3.1.207)

Links:

Pathway details at MetaCyc
Fitness data for 31 genes
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All MetaCyc pathways for Ralstonia sp. UNC404CL21Col

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information