MetaCyc Pathway: palmitate biosynthesis II (type II fatty acid synthase) in Ralstonia sp. UNC404CL21Col

Add experiment(s):


3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an acetoacetyl-[acp] + NADPH + H+→a (3R)-3-hydroxybutanoyl-[acp] + NADP+
(EC 1.1.1.100)
ABZR87_RS01455
ABZR87_RS03540
ABZR87_RS03590
ABZR87_RS07820
ABZR87_RS08385
ABZR87_RS10145
ABZR87_RS12060
ABZR87_RS12565
ABZR87_RS15380
ABZR87_RS16115
ABZR87_RS17625
ABZR87_RS17640
ABZR87_RS20660
ABZR87_RS20680
ABZR87_RS22225
ABZR87_RS22525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
ABZR87_RS11880
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-but-2-enoyl-[acp] + NADH + H+→a butanoyl-[acp] + NAD+
(EC 1.3.1.9)
ABZR87_RS10675
ABZR87_RS22515
Beta-ketoacyl-acyl-carrier-protein synthase II:
a butanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225
ABZR87_RS10155
ABZR87_RS17840
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexanoyl-[acp] + NADP+
(EC 1.1.1.100)
ABZR87_RS01455
ABZR87_RS03540
ABZR87_RS03590
ABZR87_RS07820
ABZR87_RS08385
ABZR87_RS10145
ABZR87_RS12060
ABZR87_RS12565
ABZR87_RS15380
ABZR87_RS16115
ABZR87_RS17625
ABZR87_RS17640
ABZR87_RS20660
ABZR87_RS20680
ABZR87_RS22225
ABZR87_RS22525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
ABZR87_RS11880
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hex-2-enoyl-[acp] + NADH + H+→a hexanoyl-[acp] + NAD+
(EC 1.3.1.9)
ABZR87_RS10675
ABZR87_RS22515
Beta-ketoacyl-acyl-carrier-protein synthase II:
a hexanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxooctanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225
ABZR87_RS10155
ABZR87_RS17840
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyoctanoyl-[acp] + NADP+
(EC 1.1.1.100)
ABZR87_RS01455
ABZR87_RS03540
ABZR87_RS03590
ABZR87_RS07820
ABZR87_RS08385
ABZR87_RS10145
ABZR87_RS12060
ABZR87_RS12565
ABZR87_RS15380
ABZR87_RS16115
ABZR87_RS17625
ABZR87_RS17640
ABZR87_RS20660
ABZR87_RS20680
ABZR87_RS22225
ABZR87_RS22525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
ABZR87_RS11880
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-oct-2-enoyl-[acp] + NADH + H+→an octanoyl-[acp] + NAD+
(EC 1.3.1.9)
ABZR87_RS10675
ABZR87_RS22515
Beta-ketoacyl-acyl-carrier-protein synthase II:
an octanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxodecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225
ABZR87_RS10155
ABZR87_RS17840
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxodecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydecanoyl-[acp] + NADP+
(EC 1.1.1.100)
ABZR87_RS01455
ABZR87_RS03540
ABZR87_RS03590
ABZR87_RS07820
ABZR87_RS08385
ABZR87_RS10145
ABZR87_RS12060
ABZR87_RS12565
ABZR87_RS15380
ABZR87_RS16115
ABZR87_RS17625
ABZR87_RS17640
ABZR87_RS20660
ABZR87_RS20680
ABZR87_RS22225
ABZR87_RS22525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
ABZR87_RS11880
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dec-2-enoyl-[acp] + NADH + H+→a decanoyl-[acp] + NAD+
(EC 1.3.1.9)
ABZR87_RS10675
ABZR87_RS22515
Beta-ketoacyl-acyl-carrier-protein synthase II:
a decanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxododecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225
ABZR87_RS10155
ABZR87_RS17840
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxododecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydodecanoyl-[acp] + NADP+
(EC 1.1.1.100)
ABZR87_RS01455
ABZR87_RS03540
ABZR87_RS03590
ABZR87_RS07820
ABZR87_RS08385
ABZR87_RS10145
ABZR87_RS12060
ABZR87_RS12565
ABZR87_RS15380
ABZR87_RS16115
ABZR87_RS17625
ABZR87_RS17640
ABZR87_RS20660
ABZR87_RS20680
ABZR87_RS22225
ABZR87_RS22525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydodecanoyl-[acp]→a (2E)-dodec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
ABZR87_RS11880
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dodec-2-enoyl-[acp] + NADH + H+→a dodecanoyl-[acp] + NAD+
(EC 1.3.1.9)
ABZR87_RS10675
ABZR87_RS22515
Dodecanoyl-[acyl-carrier-protein] hydrolase:
a dodecanoyl-[acp][nil] + H2O[nil]→laurate[nil] + a soluble [acyl-carrier protein][nil] + H+[nil]
(EC 3.1.2.21)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a dodecanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxotetradecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225
ABZR87_RS10155
ABZR87_RS17840
Butyrate--CoA ligase:
laurate + ATP + coenzyme A→lauroyl-CoA + AMP + diphosphate
(EC 6.2.1.2; 6.2.1.3)
ABZR87_RS02020
ABZR87_RS06225
ABZR87_RS07325
ABZR87_RS07805
ABZR87_RS17495
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxotetradecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxytetradecanoyl-[acp] + NADP+
(EC 1.1.1.100)
ABZR87_RS01455
ABZR87_RS03540
ABZR87_RS03590
ABZR87_RS07820
ABZR87_RS08385
ABZR87_RS10145
ABZR87_RS12060
ABZR87_RS12565
ABZR87_RS15380
ABZR87_RS16115
ABZR87_RS17625
ABZR87_RS17640
ABZR87_RS20660
ABZR87_RS20680
ABZR87_RS22225
ABZR87_RS22525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxytetradecanoyl-[acp]→a (2E)-tetradec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
ABZR87_RS11880
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-tetradec-2-enoyl-[acp] + NADH + H+→a myristoyl-[acp] + NAD+
(EC 1.3.1.9)
ABZR87_RS10675
ABZR87_RS22515
Beta-ketoacyl-acyl-carrier-protein synthase II:
a myristoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexadecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225
ABZR87_RS10155
ABZR87_RS17840
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexadecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexadecanoyl-[acp] + NADP+
(EC 1.1.1.100)
ABZR87_RS01455
ABZR87_RS03540
ABZR87_RS03590
ABZR87_RS07820
ABZR87_RS08385
ABZR87_RS10145
ABZR87_RS12060
ABZR87_RS12565
ABZR87_RS15380
ABZR87_RS16115
ABZR87_RS17625
ABZR87_RS17640
ABZR87_RS20660
ABZR87_RS20680
ABZR87_RS22225
ABZR87_RS22525
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexadecanoyl-[acp]→a (2E)-hexadec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
ABZR87_RS11880
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hexadec-2-enoyl-[acp] + NADH + H+→a palmitoyl-[acp] + NAD+
(EC 1.3.1.9)
ABZR87_RS10675
ABZR87_RS22515
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoyl-[acp] + H2O→palmitate + a soluble [acyl-carrier protein] + H+
(EC 3.1.2.14)
No genes
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate
(EC 6.2.1.3)
ABZR87_RS02020
ABZR87_RS06225
ABZR87_RS07325
ABZR87_RS07805
ABZR87_RS17495

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information