MetaCyc Pathway: ketogluconate metabolism in Ralstonia sp. UNC404CL21Col

MetaCyc Pathway: ketogluconate metabolism in Ralstonia sp. UNC404CL21Col

2,5-didehydrogluconate reductase (in reverse):
2,5-didehydro-D-gluconate + NADPH + H⁺→2-keto-D-gluconate + NADP⁺ (EC 1.1.1.274)

2,5-didehydro-D-gluconate + NADPH + H⁺→5-dehydro-D-gluconate + NADP⁺

2,5-didehydro-D-gluconate + NADPH + H⁺→2-keto-L-gulonate + NADP⁺ (EC 1.1.1.346)

2-keto-L-gulonate + NADPH + H⁺→L-idonate + NADP⁺

L-idonate 5-dehydrogenase:
L-idonate + NAD(P)⁺→5-dehydro-D-gluconate + NAD(P)H + H⁺ (EC 1.1.1.264)

No genes

Gluconate 5-dehydrogenase (in reverse):
5-dehydro-D-gluconate + NAD(P)H + H⁺→D-gluconate + NAD(P)⁺ (EC 1.1.1.69)

Gluconate 2-dehydrogenase (in reverse):
2-keto-D-gluconate + NADPH + H⁺→D-gluconate + NADP⁺ (EC 1.1.1.215)

Gluconokinase:
D-gluconate + ATP→D-gluconate 6-phosphate + ADP + H⁺ (EC 2.7.1.12)

Links:

Pathway details at MetaCyc
Fitness data for 6 genes
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All MetaCyc pathways for Ralstonia sp. UNC404CL21Col

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information