MetaCyc Pathway: (S)-lactate fermentation to propanoate, acetate and hydrogen in Phocaeicola vulgatus CL09T03C04

Add experiment(s):


L-lactate dehydrogenase:
(S)-lactate + NAD+→pyruvate + NADH + H+ (EC 1.1.1.27)
No genes
Pyruvate carboxylase:
pyruvate + ATP + hydrogen carbonate→oxaloacetate + ADP + H+ + phosphate (EC 6.4.1.1)
HMPREF1058_RS01450
HMPREF1058_RS03775
HMPREF1058_RS12680
HMPREF1058_RS14410
Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
HMPREF1058_RS12510
HMPREF1058_RS12515
HMPREF1058_RS18115
HMPREF1058_RS18120
formate + H+→H2 + CO2
No genes
Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
HMPREF1058_RS02165
HMPREF1058_RS08250
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
HMPREF1058_RS08505
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
HMPREF1058_RS08510
HMPREF1058_RS17920
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
HMPREF1058_RS13805
Succinate dehydrogenase (ubiquinone):
fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
No genes
succinate + propanoyl-CoA→succinyl-CoA + propanoate (EC 2.8.3.27)
HMPREF1058_RS11270
Methylmalonyl-CoA mutase (in reverse):
succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2)
HMPREF1058_RS02405
HMPREF1058_RS02410
Methylmalonyl-CoA epimerase:
(R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1)
HMPREF1058_RS16510
(S)-methylmalonyl-CoA[in] + Na+[in] + H+[out]→propanoyl-CoA[in] + CO2[in] + Na+[out] (EC 7.2.4.3)
HMPREF1058_RS01460
HMPREF1058_RS12690
HMPREF1058_RS16490
HMPREF1058_RS16495

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information