MetaCyc Pathway: GDP-L-fucose biosynthesis I (from GDP-D-mannose) in Phocaeicola vulgatus CL09T03C04

GDP-mannose 4,6-dehydratase:
GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H₂O (EC 4.2.1.47)

GDP-L-fucose synthase:
GDP-4-dehydro-α-D-rhamnose→GDP-4-dehydro-6-deoxy-β-L-galactose (EC 1.1.1.271)

GDP-L-fucose synthase (in reverse):
GDP-4-dehydro-6-deoxy-β-L-galactose + NADPH + H⁺→GDP-β-L-fucose + NADP⁺ (EC 1.1.1.271)

HMPREF1058_RS06610

HMPREF1058_RS17275

Links:

Pathway details at MetaCyc
Fitness data for 4 genes
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All MetaCyc pathways for Phocaeicola vulgatus CL09T03C04

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information