MetaCyc Pathway: L-valine degradation I in Paraburkholderia bryophila 376MFSha3.1

Add experiment(s):


Branched-chain-amino-acid transaminase:
L-valine + 2-oxoglutarate→3-methyl-2-oxobutanoate + L-glutamate (EC 2.6.1.42)
H281DRAFT_04193
H281DRAFT_05498
2-oxoisovalerate dehydrogenase (acylating):
3-methyl-2-oxobutanoate + coenzyme A + NAD+→isobutanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
isobutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→methylacrylyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
methylacrylyl-CoA + H2O→(S)-3-hydroxy-isobutanoyl-CoA (EC 4.2.1.150)
H281DRAFT_00361
H281DRAFT_00653
H281DRAFT_00756
H281DRAFT_00916
H281DRAFT_01137
H281DRAFT_01179
H281DRAFT_01187
H281DRAFT_01200
H281DRAFT_01670
H281DRAFT_01774
H281DRAFT_02068
H281DRAFT_02497
H281DRAFT_02514
H281DRAFT_02515
H281DRAFT_02677
H281DRAFT_02741
H281DRAFT_02927
H281DRAFT_03491
H281DRAFT_03701
H281DRAFT_03739
H281DRAFT_03908
H281DRAFT_04625
H281DRAFT_04627
H281DRAFT_04744
H281DRAFT_05516
H281DRAFT_05977
3-hydroxyisobutyryl-CoA hydrolase:
(S)-3-hydroxy-isobutanoyl-CoA + H2O→(S)-3-hydroxy-isobutanoate + coenzyme A + H+ (EC 3.1.2.4)
H281DRAFT_01199
3-hydroxyisobutyrate dehydrogenase:
(S)-3-hydroxy-isobutanoate + NAD+→(S)-methylmalonate-semialdehyde + NADH + H+ (EC 1.1.1.31)
H281DRAFT_00028
H281DRAFT_00361
H281DRAFT_00916
H281DRAFT_01201
H281DRAFT_01510
H281DRAFT_03517
H281DRAFT_04595
H281DRAFT_04625
(S)-3-amino-2-methylpropionate transaminase (in reverse):
(S)-methylmalonate-semialdehyde + L-glutamate→(S)-3-amino-2-methylpropanoate + 2-oxoglutarate (EC 2.6.1.22)
No genes
Methylmalonate-semialdehyde dehydrogenase (acylating):
(S)-methylmalonate-semialdehyde + coenzyme A + NAD+ + H2O→propanoyl-CoA + hydrogen carbonate + NADH + H+ (EC 1.2.1.27)
H281DRAFT_01202
H281DRAFT_02373
H281DRAFT_03264

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information