MetaCyc Pathway: valproate β-oxidation in Paraburkholderia bryophila 376MFSha3.1

Add experiment(s):


Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
H281DRAFT_00361
H281DRAFT_00373
H281DRAFT_00653
H281DRAFT_00756
H281DRAFT_00916
H281DRAFT_01137
H281DRAFT_01179
H281DRAFT_01187
H281DRAFT_01199
H281DRAFT_01200
H281DRAFT_01276
H281DRAFT_01670
H281DRAFT_01774
H281DRAFT_02068
H281DRAFT_02497
H281DRAFT_02514
H281DRAFT_02515
H281DRAFT_02677
H281DRAFT_02741
H281DRAFT_02927
H281DRAFT_03491
H281DRAFT_03701
H281DRAFT_03739
H281DRAFT_03908
H281DRAFT_04594
H281DRAFT_04595
H281DRAFT_04625
H281DRAFT_04627
H281DRAFT_04744
H281DRAFT_05516
H281DRAFT_05722
H281DRAFT_05725
H281DRAFT_05977
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
H281DRAFT_00361
H281DRAFT_00916
H281DRAFT_03517
H281DRAFT_04595
H281DRAFT_04625
H281DRAFT_06131
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
H281DRAFT_00852
H281DRAFT_00857
H281DRAFT_00917
H281DRAFT_01504
H281DRAFT_02089
H281DRAFT_04626
H281DRAFT_05130
H281DRAFT_05559
H281DRAFT_05723
H281DRAFT_06132
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
H281DRAFT_01346
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
H281DRAFT_00361
H281DRAFT_00916
H281DRAFT_03517
H281DRAFT_04595
H281DRAFT_04625
H281DRAFT_06131
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
H281DRAFT_00852
H281DRAFT_00857
H281DRAFT_00917
H281DRAFT_01504
H281DRAFT_02089
H281DRAFT_04626
H281DRAFT_05130
H281DRAFT_05518
H281DRAFT_05559
H281DRAFT_05723
H281DRAFT_06132

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information