MetaCyc Pathway: benzoate fermentation (to acetate and cyclohexane carboxylate) in Paraburkholderia bryophila 376MFSha3.1

Add experiment(s):


Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
H281DRAFT_00369
benzoyl-CoA + 2 ATP + 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H2O→cyclohex-1,5-diene-1-carbonyl-CoA + 2 ADP + 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 phosphate (EC 1.3.7.8)
No genes
Cyclohexa-1,5-dienecarbonyl-CoA hydratase (in reverse):
cyclohex-1,5-diene-1-carbonyl-CoA + H2O→6-hydroxycyclohex-1-ene-1-carbonyl-CoA (EC 4.2.1.100)
No genes
cyclohex-1,5-diene-1-carbonyl-CoA + a reduced electron-transfer flavoprotein→cyclohex-1-ene-1-carbonyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.10)
No genes
6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+→6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+ (EC 1.1.1.368)
No genes
cyclohex-1-ene-1-carbonyl-CoA + a reduced electron-transfer flavoprotein→cyclohexane-1-carbonyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.11)
No genes
cyclohexane-1-carbonyl-CoA + H2O→cyclohexane-1-carboxylate + coenzyme A + H+
No genes
6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O→2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA (EC 3.7.1.21)
No genes
2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O→3-hydroxypimeloyl-CoA + H+ (EC 3.7.1.21)
No genes
3-hydroxypimeloyl-CoA dehydrogenase:
3-hydroxypimeloyl-CoA + NAD+→3-oxopimeloyl-CoA + NADH + H+ (EC 1.1.1.259)
No genes
3-oxopimeloyl-CoA + coenzyme A→glutaryl-CoA + acetyl-CoA
H281DRAFT_00917
glutaryl-CoA + an oxidized electron-transfer flavoprotein + H+→(E)-glutaconyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.6)
No genes
(E)-glutaconyl-CoA + H+→crotonyl-CoA + CO2 (EC 1.3.8.6)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
H281DRAFT_00361
H281DRAFT_00653
H281DRAFT_00756
H281DRAFT_00916
H281DRAFT_01137
H281DRAFT_01179
H281DRAFT_01187
H281DRAFT_01670
H281DRAFT_01774
H281DRAFT_02068
H281DRAFT_02497
H281DRAFT_02514
H281DRAFT_02515
H281DRAFT_02677
H281DRAFT_02741
H281DRAFT_02927
H281DRAFT_03491
H281DRAFT_03701
H281DRAFT_03739
H281DRAFT_03908
H281DRAFT_04625
H281DRAFT_04627
H281DRAFT_04744
H281DRAFT_05516
H281DRAFT_05977
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
H281DRAFT_00361
H281DRAFT_00916
H281DRAFT_03517
H281DRAFT_04595
H281DRAFT_04625
H281DRAFT_05521
H281DRAFT_06131
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
H281DRAFT_00852
H281DRAFT_00857
H281DRAFT_00917
H281DRAFT_01504
H281DRAFT_02089
H281DRAFT_04626
H281DRAFT_05130
H281DRAFT_05518
H281DRAFT_05559
H281DRAFT_05723
H281DRAFT_06132
Acetate--CoA ligase (ADP-forming) (in reverse):
acetyl-CoA + ADP + phosphate→acetate + ATP + coenzyme A (EC 6.2.1.13)
H281DRAFT_03009

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information