MetaCyc Pathway: ceramide and sphingolipid recycling and degradation (yeast) in Paraburkholderia bryophila 376MFSha3.1

Add experiment(s):


(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + 1D-myo-inositol 1-monophosphate + H+
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + phosphoinositol-α-mannoside + H+
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[hydroxy(6-O-{6-O-[(1D-myo-inositol-1-O-yl)phosphoryl]-α-D-mannosyl}-1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + phosphoinositol-α-mannoside-phosphoinositol
No genes
Ceramidase:
a dihydroceramide + H2O→sphinganine + a carboxylate (EC 3.5.1.23)
No genes
Ceramidase:
a very-long-chain (2'R)-2'-hydroxy-phytoceramide + H2O→a phytosphingosine + a very-long-chain (2R)-2-hydroxy fatty acid (EC 3.5.1.23)
No genes
Sphinganine kinase:
sphinganine + ATP→sphinganine 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
sphinganine 1-phosphate + H2O→sphinganine + phosphate
No genes
Sphinganine kinase:
phytosphingosine + ATP→phytosphingosine (C18) 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
Sphinganine-1-phosphate aldolase:
sphinganine 1-phosphate→hexadecanal + O-phosphoethanolamine (EC 4.1.2.27)
No genes
Sphinganine-1-phosphate aldolase:
phytosphingosine (C18) 1-phosphate→(R)-2-hydroxyhexadecanal + O-phosphoethanolamine (EC 4.1.2.27)
No genes
Aldehyde dehydrogenase (NAD(+)):
hexadecanal + NAD+ + H2O→palmitate + NADH + 2 H+ (EC 1.2.1.3)
H281DRAFT_00213
H281DRAFT_00993
H281DRAFT_01117
H281DRAFT_01541
H281DRAFT_02299
H281DRAFT_02499
H281DRAFT_02944
H281DRAFT_03016
H281DRAFT_03360
H281DRAFT_03644
H281DRAFT_05056
H281DRAFT_05173
H281DRAFT_05724
H281DRAFT_05792
H281DRAFT_06513
phytosphingosine (C18) 1-phosphate + H2O→phytosphingosine + phosphate
No genes
Aldehyde dehydrogenase (NAD(+)):
(R)-2-hydroxyhexadecanal + NAD+ + H2O→(R)-2-hydroxyhexadecanoate + NADH + 2 H+ (EC 1.2.1.3)
H281DRAFT_00213
H281DRAFT_00993
H281DRAFT_01117
H281DRAFT_01541
H281DRAFT_02299
H281DRAFT_02499
H281DRAFT_02944
H281DRAFT_03016
H281DRAFT_03360
H281DRAFT_03644
H281DRAFT_05056
H281DRAFT_05173
H281DRAFT_05724
H281DRAFT_05792
H281DRAFT_06513
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
H281DRAFT_02398
H281DRAFT_05129
H281DRAFT_06226
(R)-2-hydroxyhexadecanoate + dioxygen→pentadecanoate + CO2 + H2O (EC 1.14.18.12)
No genes
Long-chain-fatty-acid--CoA ligase:
pentadecanoate + ATP + coenzyme A→pentadecanoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
H281DRAFT_02398
H281DRAFT_05129
H281DRAFT_06226

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information