MetaCyc Pathway: serotonin degradation in Paraburkholderia bryophila 376MFSha3.1

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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
H281DRAFT_00213
H281DRAFT_00993
H281DRAFT_01117
H281DRAFT_01541
H281DRAFT_02299
H281DRAFT_02499
H281DRAFT_02944
H281DRAFT_03016
H281DRAFT_03360
H281DRAFT_03644
H281DRAFT_05056
H281DRAFT_05173
H281DRAFT_05724
H281DRAFT_05792
H281DRAFT_06513
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
H281DRAFT_01050
H281DRAFT_01171
H281DRAFT_01251
H281DRAFT_02579
H281DRAFT_02988
H281DRAFT_03803
H281DRAFT_04166
H281DRAFT_05379
H281DRAFT_05508
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information