MetaCyc Pathway: γ-glutamyl cycle in Paraburkholderia bryophila 376MFSha3.1

MetaCyc Pathway: γ-glutamyl cycle in Paraburkholderia bryophila 376MFSha3.1

5-oxoprolinase (ATP-hydrolyzing):
5-oxo-L-proline + ATP + 2 H₂O→L-glutamate + ADP + H⁺ + phosphate (EC 3.5.2.9)

H281DRAFT_05811

H281DRAFT_05813

Glutamate--cysteine ligase:
L-glutamate + L-cysteine + ATP→γ-L-glutamyl-L-cysteine + ADP + H⁺ + phosphate (EC 6.3.2.2)

H281DRAFT_02011

H281DRAFT_02339

H281DRAFT_02362

Glutathione synthase:
γ-L-glutamyl-L-cysteine + ATP + glycine→glutathione + ADP + H⁺ + phosphate (EC 6.3.2.3)

H281DRAFT_02010

Gamma-glutamyltransferase:
glutathione + a proteinogenic amino acid→an α-(γ-L-glutamyl)-L-amino acid + L-cysteinylglycine (EC 2.3.2.2)

H281DRAFT_01027

H281DRAFT_01608

H281DRAFT_02485

H281DRAFT_02722

H281DRAFT_04442

an α-(γ-L-glutamyl)-L-amino acid→5-oxo-L-proline + an L-amino acid (EC 4.3.2.9)

No genes

Cytosol nonspecific dipeptidase:
L-cysteinylglycine + H₂O→L-cysteine + glycine (EC 3.4.13.18)

H281DRAFT_00123

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information