MetaCyc Pathway: glycine betaine degradation I in Paraburkholderia bryophila 376MFSha3.1

Betaine--homocysteine S-methyltransferase: glycine betaine + L-homocysteine→N,N-dimethylglycine + L-methionine (EC 2.1.1.5)

No genes

Dimethylglycine oxidase: N,N-dimethylglycine + dioxygen + a tetrahydrofolate→sarcosine + hydrogen peroxide + a 5,10-methylenetetrahydrofolate (EC 1.5.3.10)

No genes

sarcosine + dioxygen + a tetrahydrofolate→glycine + hydrogen peroxide + a 5,10-methylenetetrahydrofolate (EC 1.5.3.24)

H281DRAFT_02456

H281DRAFT_02457

Sarcosine oxidase: sarcosine + dioxygen + H2O→glycine + formaldehyde + hydrogen peroxide (EC 1.5.3.1)

H281DRAFT_01265

H281DRAFT_01266

H281DRAFT_02456

H281DRAFT_02457

H281DRAFT_02458

H281DRAFT_02459

H281DRAFT_03117

H281DRAFT_03651

H281DRAFT_05354

H281DRAFT_06330

Glycine hydroxymethyltransferase (in reverse): glycine + a 5,10-methylenetetrahydrofolate + H2O→L-serine + a tetrahydrofolate (EC 2.1.2.1)

H281DRAFT_00990

H281DRAFT_02468

H281DRAFT_04726

L-serine ammonia-lyase: L-serine→2-aminoprop-2-enoate + H2O (EC 4.3.1.17)

H281DRAFT_02407

H281DRAFT_02455

Tryptophanase: 2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)

H281DRAFT_01568

H281DRAFT_01893

H281DRAFT_02407

H281DRAFT_02455

2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)

H281DRAFT_01568

H281DRAFT_01893

H281DRAFT_02407

H281DRAFT_02455

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information