MetaCyc Pathway: superpathway of purine nucleotides de novo biosynthesis I in Bacteroides thetaiotaomicron VPI-5482

Amidophosphoribosyltransferase (in reverse): 5-phospho-α-D-ribose 1-diphosphate + L-glutamine + H2O→5-phospho-β-D-ribosylamine + L-glutamate + diphosphate (EC 2.4.2.14)

BT0555

BT4582

Phosphoribosylamine--glycine ligase: 5-phospho-β-D-ribosylamine + glycine + ATP→N1-(5-phospho-β-D-ribosyl)glycinamide + ADP + H+ + phosphate (EC 6.3.4.13)

BT3253

Phosphoribosylglycinamide formyltransferase: N1-(5-phospho-β-D-ribosyl)glycinamide + an N10-formyltetrahydrofolate→N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + H+ + a tetrahydrofolate (EC 2.1.2.2)

BT0704

BT2883

BT3360

Phosphoribosylformylglycinamidine synthase: N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + ATP + L-glutamine + H2O→2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + ADP + L-glutamate + H+ + phosphate (EC 6.3.5.3)

BT1733

Phosphoribosylformylglycinamidine cyclo-ligase: 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + ATP→5-amino-1-(5-phospho-β-D-ribosyl)imidazole + ADP + H+ + phosphate (EC 6.3.3.1)

BT4211

Phosphoribosylaminoimidazole carboxylase (in reverse): 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + CO2→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H+ (EC 4.1.1.21)

BT2518

Phosphoribosylaminoimidazolesuccinocarboxamide synthase: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate→5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole + ADP + H+ + phosphate (EC 6.3.2.6)

BT4217

Adenylosuccinate lyase: 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + fumarate (EC 4.3.2.2)

BT3871

Phosphoribosylaminoimidazolecarboxamide formyltransferase: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + an N10-formyltetrahydrofolate→5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide + a tetrahydrofolate (EC 2.1.2.3)

BT0518

BT3812

IMP cyclohydrolase (in reverse): 5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide→IMP + H2O (EC 3.5.4.10)

BT0518

BT3812

Adenylosuccinate synthase: IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)

BT1843

IMP dehydrogenase: IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)

BT3845

Adenylosuccinate lyase: adenylosuccinate→AMP + fumarate (EC 4.3.2.2)

BT3871

GMP synthase (glutamine-hydrolyzing): XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)

BT2419

BT4265

Adenylate kinase: AMP + ATP→2 ADP (EC 2.7.4.3)

BT4387

Guanylate kinase: GMP + ATP→GDP + ADP (EC 2.7.4.8)

BT2009

Ribonucleoside-diphosphate reductase (in reverse): ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)

BT2145

Nucleoside-diphosphate kinase: GDP + ATP→GTP + ADP (EC 2.7.4.6)

BT3925

Ribonucleoside-diphosphate reductase (in reverse): GDP + a reduced thioredoxin→dGDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)

BT2145

Nucleoside-diphosphate kinase: dADP + ATP→ADP + dATP (EC 2.7.4.6)

BT3925

Nucleoside-diphosphate kinase: dGDP + ATP→dGTP + ADP (EC 2.7.4.6)

BT3925

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information