MetaCyc Pathway: reductive glycine pathway of autotrophic CO2 fixation in Bacteroides thetaiotaomicron VPI-5482

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CO2 + H+ + 2 a reduced cytochrome c-553→formate + 2 an oxidized cytochrome c-553 (EC 1.17.2.3)
No genes
Formate--tetrahydrofolate ligase:
formate + ATP + a tetrahydrofolate→an N10-formyltetrahydrofolate + ADP + phosphate (EC 6.3.4.3)
BT0737
Methenyltetrahydrofolate cyclohydrolase (in reverse):
an N10-formyltetrahydrofolate + H+→a 5,10-methenyltetrahydrofolate + H2O (EC 3.5.4.9)
BT0737
BT1607
BT2691
Methylenetetrahydrofolate dehydrogenase (NADP(+)) (in reverse):
a 5,10-methenyltetrahydrofolate + NADPH→a 5,10-methylenetetrahydrofolate + NADP+ (EC 1.5.1.5)
BT1607
CO2 + a 5,10-methylenetetrahydrofolate + ammonium + NADH→glycine + NAD+ + a tetrahydrofolate (EC 1.4.1.27)
No genes
Glycine reductase (in reverse):
glycine + H+ + phosphate + a reduced thioredoxin→acetyl phosphate + ammonium + an oxidized thioredoxin + H2O (EC 1.21.4.2)
No genes
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
BT0704
BT3693
Acetate--CoA ligase:
acetate + ATP + coenzyme A→acetyl-CoA + AMP + diphosphate (EC 6.2.1.1)
BT3755
Pyruvate synthase (in reverse):
acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
BT1747

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information