MetaCyc Pathway: UMP biosynthesis II in Bacteroides thetaiotaomicron VPI-5482

Carbamoyl-phosphate synthase (glutamine-hydrolyzing): L-glutamine + 2 ATP + hydrogen carbonate + H2O→carbamoyl phosphate + 2 ADP + L-glutamate + 2 H+ + phosphate (EC 6.3.5.5)

BT0556

BT0557

BT3866

Aspartate carbamoyltransferase: carbamoyl phosphate + L-aspartate→N-carbamoyl-L-aspartate + H+ + phosphate (EC 2.1.3.2)

BT0741

BT0742

Dihydroorotase (in reverse): N-carbamoyl-L-aspartate + H+→(S)-dihydroorotate + H2O (EC 3.5.2.3)

BT0250

(S)-dihydroorotate + fumarate→orotate + succinate (EC 1.3.98.1)

BT0891

BT0892

BT1009

BT1333

Orotate phosphoribosyltransferase (in reverse): orotate + 5-phospho-α-D-ribose 1-diphosphate→orotidine 5'-phosphate + diphosphate (EC 2.4.2.10)

BT3731

Orotidine-5'-phosphate decarboxylase: orotidine 5'-phosphate + H+→UMP + CO2 (EC 4.1.1.23)

BT4209

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information