MetaCyc Pathway: L-histidine degradation III in Bacteroides thetaiotaomicron VPI-5482

Add experiment(s):


Histidine ammonia-lyase:
L-histidine→urocanate + ammonium (EC 4.3.1.3)
BT2690
Urocanate hydratase (in reverse):
urocanate + H2O→4-imidazolone-5-propanoate (EC 4.2.1.49)
BT2694
Imidazolonepropionase:
4-imidazolone-5-propanoate + H2O→N-formimino-L-glutamate (EC 3.5.2.7)
BT2692
Glutamate formimidoyltransferase (in reverse):
N-formimino-L-glutamate + a tetrahydrofolate→5-formimidoyltetrahydrofolate + L-glutamate (EC 2.1.2.5)
BT2693
Formimidoyltetrahydrofolate cyclodeaminase:
5-formimidoyltetrahydrofolate + 2 H+→a 5,10-methenyltetrahydrofolate + ammonium (EC 4.3.1.4)
BT2691
Methenyltetrahydrofolate cyclohydrolase:
a 5,10-methenyltetrahydrofolate + H2O→an N10-formyltetrahydrofolate + H+ (EC 3.5.4.9)
BT0737
BT1607
BT2691

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information