MetaCyc Pathway: docosahexaenoate biosynthesis III (6-desaturase, mammals) in Burkholderia phytofirmans PsJN

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(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + malonyl-CoA + H+→(5Z,8Z,11Z,14Z,17Z)-3-oxodocosapentaenoyl-CoA + CO2 + coenzyme A
No genes
(5Z,8Z,11Z,14Z,17Z)-3-oxodocosapentaenoyl-CoA + NAD(P)H + H+→(3R,5Z,8Z,11Z,14Z,17Z)-3-hydroxydocosapentaenoyl-CoA + NAD(P)+ (EC 1.1.1.330)
No genes
(3R,5Z,8Z,11Z,14Z,17Z)-3-hydroxydocosapentaenoyl-CoA→(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O (EC 4.2.1.134)
No genes
(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + a reduced two electron carrier→(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + an oxidized electron carrier (EC 1.3.1.93)
No genes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H+→(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + coenzyme A
No genes
(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + NADPH + H+→(3R,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosapentaenoyl-CoA + NADP+ (EC 1.1.1.330)
No genes
(3R,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosapentaenoyl-CoA→(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O (EC 4.2.1.134)
No genes
(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NADPH + H+→(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP+ (EC 1.3.1.93)
No genes
Linoleoyl-CoA desaturase:
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 a ferricytochrome b5 + 2 H2O
(EC 1.14.19.3)
No genes
Acyl-CoA oxidase:
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + dioxygen→(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + hydrogen peroxide
(EC 1.3.3.6)
No genes
Enoyl-CoA hydratase (in reverse):
(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O→(3S,6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA
(EC 4.2.1.17)
BPHYT_RS02345
BPHYT_RS03225
BPHYT_RS03235
BPHYT_RS03825
BPHYT_RS06755
BPHYT_RS06760
BPHYT_RS08375
BPHYT_RS08630
BPHYT_RS09560
BPHYT_RS10815
BPHYT_RS11780
BPHYT_RS13345
BPHYT_RS13545
BPHYT_RS14830
BPHYT_RS17335
BPHYT_RS17350
BPHYT_RS20025
BPHYT_RS25360
BPHYT_RS25695
BPHYT_RS27105
BPHYT_RS27895
BPHYT_RS28015
BPHYT_RS28020
BPHYT_RS28620
BPHYT_RS35465
(3S,6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA + NAD+→(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA + NADH + H+
No genes
Acetyl-CoA C-acyltransferase (in reverse):
(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA + coenzyme A→(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA
(EC 2.3.1.16)
BPHYT_RS02230
BPHYT_RS03230
BPHYT_RS08275
BPHYT_RS09150
BPHYT_RS09180
BPHYT_RS09565
BPHYT_RS17345
BPHYT_RS21955
BPHYT_RS29385
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + a glycerolipid→a [glycerolipid]-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + coenzyme A
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information