MetaCyc Pathway: L-phenylalanine degradation IV (mammalian, via side chain) in Burkholderia phytofirmans PsJN

MetaCyc Pathway: L-phenylalanine degradation IV (mammalian, via side chain) in Burkholderia phytofirmans PsJN

Aromatic-L-amino-acid decarboxylase:
L-phenylalanine + H⁺→2-phenylethylamine + CO₂ (EC 4.1.1.28; 4.1.1.53)

Aspartate transaminase:
L-phenylalanine + 2-oxoglutarate→3-phenyl-2-oxopropanoate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)

4-hydroxyphenylpyruvate dioxygenase:
3-phenyl-2-oxopropanoate + dioxygen→(2-hydroxyphenyl)acetate + CO₂ (EC 1.13.11.27)

Indolelactate dehydrogenase (in reverse):
3-phenyl-2-oxopropanoate + NADH + H⁺→(R)-3-(phenyl)lactate + NAD⁺ (EC 1.1.1.110)

No genes

Primary-amine oxidase:
2-phenylethylamine + dioxygen + H₂O→phenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.21; 1.4.3.4)

Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD⁺ + H₂O→phenylacetate + NADH + 2 H⁺ (EC 1.2.1.39)

Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)

Glutamine N-phenylacetyltransferase:
phenylacetyl-CoA + L-glutamine→α-N-phenylacetyl-L-glutamine + coenzyme A + H⁺ (EC 2.3.1.14)

No genes

phenylacetyl-CoA + glycine→phenylacetylglycine + coenzyme A + H⁺ (EC 2.3.1.192)

No genes

Links:

Pathway details at MetaCyc
Fitness data for 42 genes
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All MetaCyc pathways for Burkholderia phytofirmans PsJN

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information