MetaCyc Pathway: CMP-N-acetylneuraminate biosynthesis I (eukaryotes) in Burkholderia phytofirmans PsJN

Add experiment(s):


UDP-N-acetyl-α-D-glucosamine + H2O→N-acetyl-α-D-mannosamine + H+ + UDP (EC 3.2.1.183)
BPHYT_RS04315
BPHYT_RS21460
N-acylmannosamine kinase:
N-acetyl-D-mannosamine + ATP→N-acetyl-D-mannosamine 6-phosphate + ADP + H+ (EC 2.7.1.60)
No genes
N-acylneuraminate-9-phosphate synthase:
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O→N-acetyl-β-neuraminate 9-phosphate + phosphate (EC 2.5.1.57)
No genes
N-acylneuraminate-9-phosphatase:
N-acetyl-β-neuraminate 9-phosphate + H2O→N-acetyl-β-neuraminate + phosphate (EC 3.1.3.29)
No genes
N-acylneuraminate cytidylyltransferase:
N-acetyl-β-neuraminate + CTP→CMP-N-acetyl-β-neuraminate + diphosphate (EC 2.7.7.43)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information