| UDP-α-D-glucose + NAD+→UDP-3-dehydro-α-D-glucose + NADH + H+ (EC 1.1.1.M53) |
| No genes |
| UDP-3-dehydro-α-D-glucose + L-glutamine→UDP-α-D-kanosamine + 2-oxoglutaramate (EC 2.6.1.M10) |
| No genes |
| UDP-α-D-kanosamine + H2O→kanosamine + H+ + UDP (EC 3.1.4.M4) |
| No genes |
| kanosamine + ATP→D-kanosamine 6-phosphate + ADP + H+ (EC 2.7.1.179) |
| No genes |
| D-kanosamine 6-phosphate→3-amino-3-deoxy-D-fructose 6-phosphate (spontaneous) |
| No genes |
| 3-amino-3-deoxy-D-fructose 6-phosphate + aldehydo-D-ribose 5-phosphate→1-deoxy-1-imino-D-erythrose 4-phosphate + D-sedoheptulose 7-phosphate |
| No genes |
| 1-deoxy-1-imino-D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→4-amino-3,4-dideoxy-D-arabino-heptulosonate 7-phosphate + phosphate |
| No genes |
| 4-amino-3,4-dideoxy-D-arabino-heptulosonate 7-phosphate→5-deoxy-5-amino-3-dehydroquinate + phosphate (EC 4.2.1.M26) |
| No genes |
| 5-deoxy-5-amino-3-dehydroquinate→5-amino-5-deoxy-3-dehydroshikimate + H2O (EC 4.2.1.M25) |
| BPHYT_RS28845 |
| 5-amino-5-deoxy-3-dehydroshikimate→3-amino-5-hydroxybenzoate + H+ + H2O (EC 4.2.1.144) |
| No genes |
| 3-amino-5-hydroxybenzoate + ATP + a holo acp domain within a [polyketide synthase]→3-amino-5-hydroxybenzoyl-[rifamycin PKS] + AMP + diphosphate (EC 6.2.1.74) |
| No genes |
| 3-amino-5-hydroxybenzoyl-[rifamycin PKS] + 2 (S)-methylmalonyl-CoA + malonyl-CoA + NADPH + 4 H+→tetraketide-[rifamycin PKS] + 3 CO2 + 3 coenzyme A + NADP+ |
| No genes |
| tetraketide-[rifamycin PKS] + NADPH + dioxygen + H+→7-(3-amino-2,5-dihydroxyphenyl)-7-hydroxy-2,6-dimethyl-3,5-dioxoheptanoyl-[rifamycin PKS] + NADP+ + H2O (EC 1.14.13.M73) |
| No genes |
| 7-(3-amino-2,5-dihydroxyphenyl)-7-hydroxy-2,6-dimethyl-3,5-dioxoheptanoyl-[rifamycin PKS] + an oxidized electron carrier→7-(5-amino-3,6-dioxocyclohexa-1,4-dien-1-yl)-7-hydroxy-2,6-dimethyl-3,5-dioxoheptanoyl-[rifamycin PKS] + a reduced two electron carrier |
| No genes |
| 7-(5-amino-3,6-dioxocyclohexa-1,4-dien-1-yl)-7-hydroxy-2,6-dimethyl-3,5-dioxoheptanoyl-[rifamycin PKS] + 6 (S)-methylmalonyl-CoA + malonyl-CoA + 6 NADPH + 13 H+→an undecaketide-[rifamycin-PKS] + 7 CO2 + 7 coenzyme A + 6 NADP+ + 3 H2O |
| No genes |
| an undecaketide-[rifamycin-PKS]→proansamycin X + a holo acp domain within a [polyketide synthase] (EC 2.3.1.M72) |
| No genes |
| proansamycin X + NADP+→34α-deoxy-rifamycin W + NADPH + H+ |
| No genes |
| 34α-deoxy-rifamycin W + 5 dioxygen + 10 H+ + 10 a reduced ferredoxin [iron-sulfur] cluster→25-O-deacetyl-27-O-demethylrifamycin S + CO2 + 10 an oxidized ferredoxin [iron-sulfur] cluster + 7 H2O |
| No genes |
| 25-O-deacetyl-27-O-demethylrifamycin S + a reduced two electron carrier→25-O-deacetyl-27-O-demethylrifamycin SV + an oxidized electron carrier |
| No genes |
| 25-O-deacetyl-27-O-demethylrifamycin SV + acetyl-CoA→27-O-demethyl-rifamycin SV + coenzyme A |
| No genes |
| 27-O-demethyl-rifamycin SV + S-adenosyl-L-methionine→rifamycin SV + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.315) |
| No genes |
| rifamycin SV + dioxygen→rifamycin S + hydrogen peroxide (spontaneous) |
| No genes |
| rifamycin S + D-xylulose 5-phosphate→rifamycin L + D-glyceraldehyde 3-phosphate |
| No genes |
| rifamycin L + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→rifamycin O + 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H2O |
| No genes |
| rifamycin O + NADPH→rifamycin B + NADP+ (spontaneous) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information