MetaCyc Pathway: superpathway of glyoxylate bypass and TCA in Shewanella sp. ANA-3

Add experiment(s):


2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
Shewana3_0428
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
Shewana3_1712 (sucC)
Shewana3_1713
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
Shewana3_2302
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
Shewana3_0750
Shewana3_3509
(S)-malate[in] + an electron-transfer quinone→oxaloacetate[in] + an electron-transfer quinol (EC 1.1.5.4)
No genes
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
Shewana3_1705 (gltA)
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
Shewana3_0433
Shewana3_3827
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
Shewana3_0433
Shewana3_3827
Isocitrate lyase:
D-threo-isocitrate→succinate + glyoxylate (EC 4.1.3.1)
Shewana3_2942
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
Shewana3_1750
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9)
Shewana3_2943
Shewana3_4060

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information