MetaCyc Pathway: L-tryptophan biosynthesis in Pseudomonas fluorescens FW300-N2E2

Add experiment(s):


Reactions and Genes Ammonium chloride (N)
remove
Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27)
Pf6N2E2_1717 -1.9
Pf6N2E2_1718 -2.0
Pf6N2E2_4822 -0.2
Pf6N2E2_4824 -0.6
Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18)
Pf6N2E2_304 -0.6
Pf6N2E2_4825 -5.7
Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24)
Pf6N2E2_71 -5.0
Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (EC 4.1.1.48)
Pf6N2E2_4826 -5.3
Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20)
Pf6N2E2_3982 +0.3
Pf6N2E2_4047 -5.1
Pf6N2E2_4048 -4.0
Pf6N2E2_5238 -0.3
indole + L-serine→L-tryptophan + H2O (EC 4.2.1.122; 4.2.1.20)
Pf6N2E2_3982 +0.3
Pf6N2E2_4047 -5.1
Pf6N2E2_4048 -4.0
Pf6N2E2_5238 -0.3

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information