MetaCyc Pathway: L-phenylalanine degradation IV (mammalian, via side chain) in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Cadmium chloride hemipentahydrate 0.000015625 M
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Aromatic-L-amino-acid decarboxylase:
L-phenylalanine + H+→2-phenylethylamine + CO2 (EC 4.1.1.28; 4.1.1.53)
No genes
Aspartate transaminase:
L-phenylalanine + 2-oxoglutarate→3-phenyl-2-oxopropanoate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
Pf6N2E2_1496 -0.1
Pf6N2E2_2127 +2.4
Pf6N2E2_2446 +0.0
Pf6N2E2_2519 +0.1
Pf6N2E2_2632 -0.3
Pf6N2E2_3173 +0.2
Pf6N2E2_3251 +0.7
Pf6N2E2_4288 +0.1
Pf6N2E2_4386 -0.1
Pf6N2E2_462 +0.0
Pf6N2E2_50 -0.2
Pf6N2E2_5300 +1.6
Pf6N2E2_5813 +0.0
Pf6N2E2_5890 -0.1
Pf6N2E2_5891 N.D.
Pf6N2E2_5895 +0.1
Pf6N2E2_5989 +2.2
Pf6N2E2_637 -0.0
Pf6N2E2_684 -0.0
4-hydroxyphenylpyruvate dioxygenase:
3-phenyl-2-oxopropanoate + dioxygen→(2-hydroxyphenyl)acetate + CO2 (EC 1.13.11.27)
Pf6N2E2_1001 -0.3
Pf6N2E2_456 -0.1
Pf6N2E2_5058 +0.1
Pf6N2E2_988 -0.1
Indolelactate dehydrogenase (in reverse):
3-phenyl-2-oxopropanoate + NADH + H+→(R)-3-(phenyl)lactate + NAD+ (EC 1.1.1.110)
No genes
Primary-amine oxidase:
2-phenylethylamine + dioxygen + H2O→phenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.21; 1.4.3.4)
Pf6N2E2_4632 -0.0
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+ (EC 1.2.1.39)
Pf6N2E2_1329 +0.2
Pf6N2E2_1381 -0.2
Pf6N2E2_1764 +0.3
Pf6N2E2_4979 -0.0
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
Pf6N2E2_1716 +0.0
Glutamine N-phenylacetyltransferase:
phenylacetyl-CoA + L-glutamine→α-N-phenylacetyl-L-glutamine + coenzyme A + H+ (EC 2.3.1.14)
No genes
phenylacetyl-CoA + glycine→phenylacetylglycine + coenzyme A + H+ (EC 2.3.1.192)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information