MetaCyc Pathway: superpathway of L-lysine, L-threonine and L-methionine biosynthesis I in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes chromate 0.0000015625 M
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate
(EC 2.6.1.1)
Pf6N2E2_1496 -0.1
Pf6N2E2_2127 +3.1
Pf6N2E2_2446 +0.0
Pf6N2E2_2632 +0.0
Pf6N2E2_3173 +0.1
Pf6N2E2_4288 +0.0
Pf6N2E2_4386 -0.3
Pf6N2E2_462 +0.0
Pf6N2E2_5300 +1.6
Pf6N2E2_5813 -0.1
Pf6N2E2_5890 -0.2
Pf6N2E2_5891 N.D.
Pf6N2E2_5895 +0.0
Pf6N2E2_5989 +2.2
Pf6N2E2_637 +0.0
Pf6N2E2_684 +0.1
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
Pf6N2E2_5676 -0.1
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
Pf6N2E2_2844 +0.2
Pf6N2E2_4232 -0.1
Pf6N2E2_67 N.D.
Pf6N2E2_68 -0.1
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
Pf6N2E2_2747 N.D.
Pf6N2E2_3203 -0.0
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+
(EC 1.1.1.3)
Pf6N2E2_3143 N.D.
Pf6N2E2_4963 -0.4
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+
(EC 2.7.1.39)
Pf6N2E2_4164 N.D.
Pf6N2E2_6055 +0.3
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A
(EC 2.3.1.46)
No genes
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
Pf6N2E2_3366 N.D.
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate
(EC 2.5.1.48)
Pf6N2E2_4958 +0.0
Pf6N2E2_77 +1.4
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2ON-succinyl-2-amino-6-ketopimelate + coenzyme A
(EC 2.3.1.117)
Pf6N2E2_3078 N.D.
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate
(EC 4.2.3.1)
Pf6N2E2_3142 N.D.
Pf6N2E2_4961 +0.1
Pf6N2E2_5296 +0.2
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate
(EC 4.4.1.13)
No genes
Succinyldiaminopimelate transaminase (in reverse):
N-succinyl-2-amino-6-ketopimelate + L-glutamateN-succinyl-L,L-2,6-diaminopimelate + 2-oxoglutarate
(EC 2.6.1.17)
Pf6N2E2_3073 -0.1
Pf6N2E2_5665 +0.0
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate
(EC 2.1.1.14)
Pf6N2E2_5472 -0.0
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate
(EC 2.1.1.13)
Pf6N2E2_2068 +0.2
Succinyl-diaminopimelate desuccinylase:
N-succinyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + succinate
(EC 3.5.1.18)
Pf6N2E2_3083 N.D.
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
Pf6N2E2_2885 +0.2
Pf6N2E2_33 -0.2
Pf6N2E2_4418 -1.0
Pf6N2E2_6030 +0.2
Pf6N2E2_758 -0.1
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
Pf6N2E2_4419 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information