MetaCyc Pathway: adipate biosynthesis in Sinorhizobium meliloti 1021

Reactions and Genes	Protocatechuic Acid (C)
3-oxoadipyl-CoA thiolase: acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A (EC 2.3.1.174)
SM_b20589	-5.0
3-hydroxyacyl-CoA dehydrogenase (in reverse): 3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+ (EC 1.1.1.35)
SM_b21632	+0.1
SMc01638	+0.0
SMc02227	-0.7
Enoyl-CoA hydratase: (3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O (EC 4.2.1.17)
SM_b20752	+0.1
SM_b21632	+0.1
SM_b21633	+0.2
SMa1408	-0.0
SMc00976	-0.5
SMc01153	+0.1
SMc01638	+0.0
SMc01641	+0.8
SMc01669	+0.1
SMc01806	+0.2
SMc02227	-0.7
SMc04398	N.D.
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
No genes
Succinate--CoA ligase (ADP-forming) (in reverse): adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A (EC 6.2.1.5)
SMc02480	N.D.
SMc02481	N.D.

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information