MetaCyc Pathway: propanoate fermentation to 2-methylbutanoate in Sinorhizobium meliloti 1021

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Reactions and Genes Protocatechuic Acid (C)
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Propionate CoA-transferase:
propanoate + acetyl-CoA→acetate + propanoyl-CoA (EC 2.8.3.1)
No genes
Acetyl-CoA C-acyltransferase:
propanoyl-CoA + acetyl-CoA→2-methylacetoacetyl-CoA + coenzyme A (EC 2.3.1.16)
SM_b20589 -5.0
SMa1450 +0.0
SMc00262 -0.1
SMc00966 -0.2
SMc02228 -0.9
SMc03879 -0.5
3-hydroxy-2-methylbutyryl-CoA dehydrogenase (in reverse):
2-methylacetoacetyl-CoA + NADH + H+→(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ (EC 1.1.1.178)
SM_b21632 +0.1
SMa1452 +0.2
SMc02227 -0.7
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA→(E)-2-methylcrotonoyl-CoA + H2O (EC 4.2.1.150)
SM_b21632 +0.1
SM_b21633 +0.2
SMc00976 -0.5
SMc01638 +0.0
SMc01669 +0.1
SMc01806 +0.2
SMc02227 -0.7
(E)-2-methylcrotonoyl-CoA + a reduced electron-transfer flavoprotein→(2S)-2-methylbutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.5)
No genes
(2S)-2-methylbutanoyl-CoA + H2O→2-methylbutanoate + coenzyme A + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information