MetaCyc Pathway: benzoyl-CoA degradation I (aerobic) in Sinorhizobium meliloti 1021

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Reactions and Genes Protocatechuic Acid (C)
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benzoyl-CoA + NADPH + dioxygen + H+→2,3-epoxy-2,3-dihydrobenzoyl-CoA + NADP+ + H2O (EC 1.14.13.208)
No genes
2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O→cis-3,4-dehydroadipyl-CoA semialdehyde + formate + H+ (EC 4.1.2.44)
No genes
cis-3,4-dehydroadipyl-CoA semialdehyde + NADP+ + H2O→cis-3,4-dehydroadipyl-CoA + NADPH + 2 H+ (EC 1.2.1.77)
No genes
cis-3,4-dehydroadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
SM_b20752 +0.1
SM_b21632 +0.1
SM_b21633 +0.2
SMa1408 -0.0
SMc00976 -0.5
SMc01153 +0.1
SMc01638 +0.0
SMc01641 +0.8
SMc01669 +0.1
SMc01806 +0.2
SMc02227 -0.7
SMc04398 N.D.
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
SM_b21632 +0.1
SMc01638 +0.0
SMc02227 -0.7
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
SM_b20589 -5.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information