MetaCyc Pathway: trans-4-hydroxy-L-proline degradation I in Sinorhizobium meliloti 1021

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Reactions and Genes pipercolic (C)
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trans-4-hydroxy-L-proline[in] + an electron-transfer quinone→(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.3)
No genes
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + H+ + H2O→L-4-hydroxyglutamate semialdehyde (spontaneous)
No genes
L-4-hydroxyglutamate semialdehyde + NAD+ + H2O→erythro-4-hydroxy-L-glutamate + NADH + 2 H+
No genes
4-hydroxyglutamate transaminase:
erythro-4-hydroxy-L-glutamate + 2-oxoglutarate→(4R)-4-hydroxy-2-oxoglutarate + L-glutamate (EC 2.6.1.23)
SM_b20039 +0.2
SMc00294 -2.4
SMc00490 +0.3
SMc01406 -0.0
SMc01578 -0.5
SMc01969 -0.5
SMc02251 +0.0
SMc02262 -0.1
SMc02393 -0.1
SMc04326 +0.0
SMc04386 -2.4
4-hydroxy-2-oxoglutarate aldolase:
(4R)-4-hydroxy-2-oxoglutarate→glyoxylate + pyruvate (EC 4.1.3.16)
SMc02043 N.D.
SMc03153 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information