MetaCyc Pathway: superpathway of fatty acids biosynthesis (E. coli) in Ralstonia sp. UNC404CL21Col

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Reactions and Genes Lauric (C)
remove
acetyl-CoA + a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
ABZR87_RS10655 N.D.
ABZR87_RS14485 N.D.
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a soluble [acyl-carrier protein]→a malonyl-[acp] + coenzyme A (EC 2.3.1.39)
ABZR87_RS10140 N.D.
ABZR87_RS23475 -3.1
Beta-ketoacyl-acyl-carrier-protein synthase III:
acetyl-CoA + a malonyl-[acp] + H+→an acetoacetyl-[acp] + CO2 + coenzyme A (EC 2.3.1.180)
ABZR87_RS10135 N.D.
ABZR87_RS17840 +0.0
ABZR87_RS21860 -0.2
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an acetoacetyl-[acp] + NADPH + H+→a (3R)-3-hydroxybutanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-but-2-enoyl-[acp] + NADH + H+→a butanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a butanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hex-2-enoyl-[acp] + NADH + H+→a hexanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a hexanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxooctanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyoctanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-oct-2-enoyl-[acp] + NADH + H+→an octanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
an octanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxodecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxodecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydecanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a (2E)-dec-2-enoyl-[acp]→a (3Z)-dec-3-enoyl-[acp] (EC 5.3.3.14)
No genes
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dec-2-enoyl-[acp] + NADH + H+→a decanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a decanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxododecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (3Z)-dec-3-enoyl-[acp] + a malonyl-[acp] + H+→a (5Z)-3-oxododec-5-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxododecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydodecanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (5Z)-3-oxododec-5-enoyl-[acp] + NADPH + H+→a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydodecanoyl-[acp]→a (2E)-dodec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp]→a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dodec-2-enoyl-[acp] + NADH + H+→a dodecanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + NADH + H+→a (5Z)-dodec-5-enoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Dodecanoyl-[acyl-carrier-protein] hydrolase:
a dodecanoyl-[acp][nil] + H2O[nil]→laurate[nil] + a soluble [acyl-carrier protein][nil] + H+[nil] (EC 3.1.2.21)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (5Z)-dodec-5-enoyl-[acp] + a malonyl-[acp] + H+→a (7Z)-3-oxotetradec-7-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a dodecanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxotetradecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (7Z)-3-oxotetradec-7-enoyl-[acp] + NADPH + H+→a (3R,7Z)-3-hydroxytetradec-7-enoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
Butyrate--CoA ligase:
laurate + ATP + coenzyme A→lauroyl-CoA + AMP + diphosphate (EC 6.2.1.2; 6.2.1.3)
ABZR87_RS02020 -0.1
ABZR87_RS06225 -0.1
ABZR87_RS07325 +0.1
ABZR87_RS07805 +0.2
ABZR87_RS17495 -0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxotetradecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxytetradecanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,7Z)-3-hydroxytetradec-7-enoyl-[acp]→a (2E,7Z)-tetradeca-2,7-dienoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxytetradecanoyl-[acp]→a (2E)-tetradec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,7Z)-tetradeca-2,7-dienoyl-[acp] + NADH + H+→a (7Z)-tetradec-7-enoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-tetradec-2-enoyl-[acp] + NADH + H+→a myristoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (7Z)-tetradec-7-enoyl-[acp] + a malonyl-[acp] + H+→a (9Z)-3-oxohexadec-9-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a myristoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexadecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABZR87_RS07225 +0.0
ABZR87_RS10155 N.D.
ABZR87_RS17840 +0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (9Z)-3-oxohexadec-9-enoyl-[acp] + NADPH + H+→a (3R,9Z)-3-hydroxyhexadec-9-enoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexadecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexadecanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexadecanoyl-[acp]→a (2E)-hexadec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,9Z)-3-hydroxyhexadec-9-enoyl-[acp]→a (2E,9Z)-hexadeca-2,9-dienoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,9Z)-hexadeca-2,9-dienoyl-[acp] + NADH + H+→a palmitoleoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hexadec-2-enoyl-[acp] + NADH + H+→a palmitoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoyl-[acp] + H2O→palmitate + a soluble [acyl-carrier protein] + H+ (EC 3.1.2.14)
No genes
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoleoyl-[acp] + H2O→palmitoleate + a soluble [acyl-carrier protein] + H+ (EC 3.1.2.14)
ABZR87_RS12755 +0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a palmitoleoyl-[acp] + a malonyl-[acp] + H+→an (11Z)-3-oxooctadec-11-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179)
ABZR87_RS10155 N.D.
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
ABZR87_RS02020 -0.1
ABZR87_RS06225 -0.1
ABZR87_RS07325 +0.1
ABZR87_RS07805 +0.2
ABZR87_RS17495 -0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an (11Z)-3-oxooctadec-11-enoyl-[acp] + NADPH + H+→a (3R,11Z)-3-hydroxyoctadec-11-enoyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 -0.0
ABZR87_RS03540 -0.1
ABZR87_RS03590 -0.4
ABZR87_RS07820 -0.1
ABZR87_RS08385 -0.0
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.1
ABZR87_RS12565 +0.1
ABZR87_RS15380 +0.2
ABZR87_RS16115 +0.0
ABZR87_RS17625 +0.5
ABZR87_RS17640 +0.1
ABZR87_RS20660 N.D.
ABZR87_RS20680 -0.3
ABZR87_RS22225 +0.1
ABZR87_RS22525 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,11Z)-3-hydroxyoctadec-11-enoyl-[acp]→a (2E,11Z)-octadeca-2,11-dienoyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,11Z)-octadeca-2,11-dienoyl-[acp] + NADH + H+→a cis-vaccenoyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 -0.2
Oleoyl-[acyl-carrier-protein] hydrolase:
a cis-vaccenoyl-[acp] + H2O→cis-vaccenate + a soluble [acyl-carrier protein] + H+ (EC 3.1.2.14)
ABZR87_RS12755 +0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information