MetaCyc Pathway: glutaryl-CoA degradation in Sinorhizobium meliloti 1021

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Reactions and Genes L-Lysine (C)
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glutaryl-CoA + an oxidized electron-transfer flavoprotein + H+→(E)-glutaconyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.6)
No genes
(E)-glutaconyl-CoA + H+→crotonyl-CoA + CO2 (EC 1.3.8.6)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
SM_b21632 +0.1
SM_b21633 +0.6
SMc00976 +0.4
SMc01638 -0.0
SMc01669 -0.2
SMc01806 +0.1
SMc04398 N.D.
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
SM_b21632 +0.1
SMc00727 -0.4
SMc01638 -0.0
SMc02227 -1.5
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
SM_b20589 +0.0
SMa1450 +0.1
SMc00262 -0.5
SMc00966 -0.1
SMc02228 -1.2
SMc03879 -5.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information