MetaCyc Pathway: adipate degradation in Sinorhizobium meliloti 1021

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Reactions and Genes Myristic (C)
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Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)
SMc02480 N.D.
SMc02481 N.D.
adipoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
SMc00977 -5.7
SMc01359 N.D.
SMc02229 -5.5
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
SM_b20752 -1.3
SM_b21632 +0.2
SM_b21633 +0.4
SMa1408 +0.0
SMc00976 +1.1
SMc01153 -1.8
SMc01638 -0.1
SMc01641 +0.2
SMc01669 +0.3
SMc01806 +0.1
SMc02227 -5.1
SMc04398 N.D.
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
SM_b21632 +0.2
SMc01638 -0.1
SMc02227 -5.1
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
SM_b20589 -0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information