MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pantoea sp. MT58

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Reactions and Genes Survival; Treatment=UGA synthetic gw pH7.4 with 1 mM Glucose and 5 mM NaH2PO4; TreatmentDuration=24hrs; Outgrowth=LBkan50
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
IAI47_00100 -0.1
IAI47_01085 -0.0
IAI47_01110 -0.2
IAI47_03280 +0.2
IAI47_03285 +0.2
IAI47_06185 +0.0
IAI47_06350 +0.1
IAI47_09620 -0.1
IAI47_12765 +0.2
IAI47_16465 -0.1
IAI47_18095 +0.2
IAI47_19280 +0.1
IAI47_19310 -0.1
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
IAI47_00885 -1.4
IAI47_16215 -0.1
IAI47_17960 +0.0
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
IAI47_01675 N.D.
IAI47_06240 -1.0
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
IAI47_00885 -1.4
IAI47_16215 -0.1
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
IAI47_16210 +0.1
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
IAI47_16205 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information