MetaCyc Pathway: L-lysine biosynthesis VI in Pantoea sp. MT58

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Reactions and Genes Survival; Treatment=UGA synthetic gw pH7.4 with 1 mM Glucose and 0 mM NaH2PO4; TreatmentDuration=24hrs; Outgrowth=LBkan50
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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
IAI47_00885 -1.5
IAI47_16215 -0.1
IAI47_17960 -0.2
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
IAI47_01675 N.D.
IAI47_06240 -0.4
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
IAI47_04285 -0.0
IAI47_05265 N.D.
IAI47_10125 +0.1
IAI47_15745 +0.1
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
IAI47_16125 N.D.
LL-diaminopimelate aminotransferase (in reverse):
(S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H+ + H2O→L,L-diaminopimelate + 2-oxoglutarate
(EC 2.6.1.83)
No genes
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
IAI47_08495 N.D.
IAI47_18410 -0.5
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
IAI47_03860 -0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information