MetaCyc Pathway: superpathway of L-methionine biosynthesis (transsulfuration) in Pantoea sp. MT58

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Reactions and Genes Survival; Treatment=UGA synthetic gw pH7.4 with 1 mM Glucose and 0 mM NaH2PO4; TreatmentDuration=24hrs; Outgrowth=LBkan50
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
IAI47_00100 -0.1
IAI47_01085 +0.0
IAI47_01110 +0.1
IAI47_03280 -0.0
IAI47_03285 +0.1
IAI47_06185 -0.2
IAI47_06350 +0.0
IAI47_09620 +0.1
IAI47_12765 +0.0
IAI47_16465 -0.0
IAI47_18095 +0.1
IAI47_19280 +0.1
IAI47_19310 +0.0
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
IAI47_00885 -1.6
IAI47_16215 +0.0
IAI47_17960 +0.0
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
IAI47_01675 N.D.
IAI47_06240 -0.3
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
IAI47_00885 -1.6
IAI47_16215 +0.0
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46)
IAI47_18015 +0.3
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
IAI47_00880 -0.0
IAI47_15695 -0.0
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
IAI47_03215 +0.0
IAI47_10360 -0.3
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
IAI47_14840 -0.2
IAI47_18310 +0.1
IAI47_20755 -0.0
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13)
IAI47_17990 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information