MetaCyc Pathway: superpathway of L-arginine and L-ornithine degradation in Pseudomonas fluorescens FW300-N2C3

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Reactions and Genes 20 mM putrescine
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Arginine decarboxylase:
L-arginine + H+→agmatine + CO2 (EC 4.1.1.19)
AO356_07310 +0.1
AO356_08155 -0.3
Ornithine decarboxylase:
L-ornithine + H+→putrescine + CO2 (EC 4.1.1.17)
AO356_07310 +0.1
Agmatinase:
agmatine + H2O→putrescine + urea (EC 3.5.3.11)
AO356_04095 +0.0
Putrescine aminotransferase:
putrescine + 2-oxoglutarate→4-aminobutanal + L-glutamate (EC 2.6.1.82)
AO356_18100 +0.1
Glutamate--putrescine ligase:
putrescine + ATP + L-glutamate→γ-glutamyl-L-putrescine + ADP + H+ + phosphate (EC 6.3.1.11)
AO356_13135 -3.4
Aminobutyraldehyde dehydrogenase:
4-aminobutanal + NAD+ + H2O→4-aminobutanoate + NADH + 2 H+ (EC 1.2.1.19)
AO356_06290 -0.1
AO356_06315 -0.2
AO356_09270 -0.0
AO356_12580 -3.0
AO356_15145 +0.1
AO356_15225 +0.1
AO356_25765 +0.0
AO356_26445 +0.1
AO356_26800 +0.5
AO356_27135 +0.2
AO356_27520 -0.0
AO356_28025 -0.3
AO356_28685 +0.2
AO356_28710 +1.0
AO356_29070 -0.1
AO356_30220 +0.0
AO356_30285 +0.1
4-aminobutanal→1-pyrroline + H2O (spontaneous)
No genes
γ-glutamyl-L-putrescine + dioxygen + H2O→4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide (EC 1.4.3.M3)
AO356_21495 -3.5
4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O→4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ (EC 1.2.1.99)
AO356_12580 -3.0
Gamma-glutamyl-gamma-aminobutyrate hydrolase:
4-(γ-L-glutamylamino)butanoate + H2O→4-aminobutanoate + L-glutamate (EC 3.5.1.94)
AO356_13140 -1.9
4-aminobutyrate transaminase:
4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19)
AO356_10035 +0.0
AO356_10715 -0.3
AO356_13150 -2.8
AO356_16720 -0.1
AO356_26715 -0.0
AO356_27515 +0.3
Succinate-semialdehyde dehydrogenase:
succinate semialdehyde + NAD+ + H2O→succinate + NADH + 2 H+ (EC 1.2.1.24)
No genes
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
AO356_26740 -0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information