MetaCyc Pathway: superpathway of L-citrulline metabolism in Pseudomonas fluorescens SBW25-INTG

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Reactions and Genes acetate (C)
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Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
PFLU_RS02045 -2.2
PFLU_RS02050 -2.6
PFLU_RS04290 N.D.
PFLU_RS04295 N.D.
PFLU_RS04300 N.D.
PFLU_RS05320 +0.7
PFLU_RS05490 +0.2
PFLU_RS06365 N.D.
PFLU_RS06610 +0.3
PFLU_RS06710 -0.2
PFLU_RS06830 +0.0
PFLU_RS06835 +0.1
PFLU_RS08375 -0.3
PFLU_RS08710 -0.0
PFLU_RS11415 -0.0
PFLU_RS11420 +0.1
PFLU_RS12015 -0.0
PFLU_RS15070 +0.0
PFLU_RS16015 +0.0
PFLU_RS17490 +0.1
PFLU_RS19210 +0.1
PFLU_RS19255 +0.4
PFLU_RS19480 -0.2
PFLU_RS20385 -0.2
PFLU_RS21200 +0.1
PFLU_RS21955 +0.1
PFLU_RS22715 -0.2
PFLU_RS22835 +0.3
PFLU_RS23455 -0.2
PFLU_RS23780 +0.5
PFLU_RS24590 +0.5
PFLU_RS24730 N.D.
PFLU_RS25880 N.D.
PFLU_RS25885 N.D.
PFLU_RS26915 -0.0
PFLU_RS27375 -1.2
PFLU_RS27380 -1.5
PFLU_RS30020 +0.0
Carbamoyl-phosphate synthase (ammonia):
ammonium + 2 ATP + hydrogen carbonate→carbamoyl phosphate + 2 ADP + 2 H+ + phosphate (EC 6.3.4.16)
No genes
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
PFLU_RS02230 -0.0
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
PFLU_RS25360 -2.8
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
PFLU_RS26675 N.D.
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
PFLU_RS23315 -0.9
PFLU_RS27595 -1.1
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
PFLU_RS05680 N.D.
PFLU_RS23975 -0.1
Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H+ (EC 6.3.4.5)
PFLU_RS05725 N.D.
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)
PFLU_RS29220 N.D.
Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
PFLU_RS05560 N.D.
PFLU_RS15885 -0.5
Nitric-oxide synthase:
2 L-arginine + 3 NADPH + 4 dioxygen + H+→2 L-citrulline + 3 NADP+ + 2 nitric oxide + 4 H2O (EC 1.14.13.39)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information