MetaCyc Pathway: pentachlorophenol degradation in Ralstonia sp. UNC404CL21Col

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Reactions and Genes Protocatechuic Acid (C)
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Pentachlorophenol monooxygenase:
pentachlorophenol + NADPH + dioxygen + H+→2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + NADP+ + H2O
(EC 1.14.13.50)
No genes
2,3,5,6-tetrachloro-1,4-benzoquinone + NADH→2,3,5,6-tetrachlorohydroquinone + NAD+ + H+ (EC 1.1.1.404)
No genes
2,3,5,6-tetrachlorohydroquinone + glutathione + H+→2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone + chloride (EC 1.21.4.5; 2.5.1.18)
ABZR87_RS01320 -0.0
ABZR87_RS03165 -0.0
ABZR87_RS04030 +0.0
ABZR87_RS04895 -0.2
ABZR87_RS05510 -1.6
ABZR87_RS06010 +0.0
ABZR87_RS06920 +0.2
ABZR87_RS08295 -0.0
ABZR87_RS09810 +0.5
ABZR87_RS12540 +0.0
ABZR87_RS14650 -0.1
ABZR87_RS14710 -0.3
ABZR87_RS18480 +0.3
ABZR87_RS21830 -0.0
ABZR87_RS23150 -0.2
ABZR87_RS23410 +0.2
2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone + glutathione→2,3,6-trichlorohydroquinone + glutathione disulfide + H+ (EC 1.21.4.5; 1.8.5.7)
No genes
2,3,6-trichlorohydroquinone + glutathione→2,6-dichloro-3-(glutathion-S-yl)-hydroquinone + chloride (EC 1.21.4.5; 2.5.1.18)
ABZR87_RS01320 -0.0
ABZR87_RS03165 -0.0
ABZR87_RS04030 +0.0
ABZR87_RS04895 -0.2
ABZR87_RS05510 -1.6
ABZR87_RS06010 +0.0
ABZR87_RS06920 +0.2
ABZR87_RS08295 -0.0
ABZR87_RS09810 +0.5
ABZR87_RS12540 +0.0
ABZR87_RS14650 -0.1
ABZR87_RS14710 -0.3
ABZR87_RS18480 +0.3
ABZR87_RS21830 -0.0
ABZR87_RS23150 -0.2
ABZR87_RS23410 +0.2
2,6-dichloro-3-(glutathion-S-yl)-hydroquinone + glutathione→2,6-dichlorohydroquinone + glutathione disulfide + H+ (EC 1.21.4.5; 1.8.5.7)
No genes
2,6-dichlorohydroquinone + dioxygen + H2O→2-chloromaleylacetate + chloride + 2 H+
No genes
Maleylacetate reductase (in reverse):
2-chloromaleylacetate + NAD(P)H + H+→5-chloro-3-oxoadipate + NAD(P)+
(EC 1.3.1.32)
No genes
5-chloro-3-oxoadipate→2-maleylacetate + chloride + H+ (spontaneous)
No genes
Maleylacetate reductase (in reverse):
2-maleylacetate + NAD(P)H + H+→3-oxoadipate + NAD(P)+
(EC 1.3.1.32)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information