MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis IV in Ralstonia sp. UNC404CL21Col

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Reactions and Genes Sebacic (C)
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glutaryl-CoA + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] + CO2 + coenzyme A
ABZR87_RS10135 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] + NADP+ (EC 1.1.1.100)
ABZR87_RS01455 +0.5
ABZR87_RS03540 -0.2
ABZR87_RS03590 +0.6
ABZR87_RS07820 -0.3
ABZR87_RS08385 +0.4
ABZR87_RS10145 N.D.
ABZR87_RS12060 -0.0
ABZR87_RS12565 +0.3
ABZR87_RS15380 +0.1
ABZR87_RS16115 +0.1
ABZR87_RS17625 -0.8
ABZR87_RS17640 -0.4
ABZR87_RS20660 N.D.
ABZR87_RS20680 +0.8
ABZR87_RS22225 -0.1
ABZR87_RS22525 +0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp]→a 2-enoyl-pimeloyl-[acp] + H2O (EC 4.2.1.59)
ABZR87_RS11880 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a 2-enoyl-pimeloyl-[acp] + NADH + H+→a pimeloyl-[acp] + NAD+ (EC 1.3.1.9)
ABZR87_RS10675 N.D.
ABZR87_RS22515 +0.0
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
ABZR87_RS12340 -2.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information