MetaCyc Pathway: serotonin degradation in Phaeobacter inhibens DSM 17395

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Reactions and Genes Putrescine (N)
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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
PGA1_c21070 -0.1
PGA1_c23350 N.D.
PGA1_c26830 -0.1
PGA1_c27190 N.D.
PGA1_c32120 +0.0
PGA1_c32250 -0.1
PGA1_c32800 -0.2
PGA1_c33040 -2.5
PGA1_262p00230 -0.4
PGA1_262p00800 +0.2
PGA1_262p01380 -0.0
PGA1_262p01460 -0.3
PGA1_262p01790 +0.2
PGA1_78p00120 -0.4
PGA1_c05130 +0.1
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
PGA1_c19350 -0.2
PGA1_c23360 N.D.
PGA1_c27200 N.D.
PGA1_c04550 -0.1
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information