MetaCyc Pathway: 5-aminoimidazole ribonucleotide biosynthesis I in Bacteroides thetaiotaomicron VPI-5482

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Reactions and Genes BHIS with Trimethoprim 0.00625 mM
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Amidophosphoribosyltransferase (in reverse):
5-phospho-α-D-ribose 1-diphosphate + L-glutamine + H2O→5-phospho-β-D-ribosylamine + L-glutamate + diphosphate (EC 2.4.2.14)
BT0555 +0.5
BT4582 +1.8
Phosphoribosylamine--glycine ligase:
5-phospho-β-D-ribosylamine + glycine + ATP→N1-(5-phospho-β-D-ribosyl)glycinamide + ADP + H+ + phosphate (EC 6.3.4.13)
BT3253 +2.5
Phosphoribosylglycinamide formyltransferase:
N1-(5-phospho-β-D-ribosyl)glycinamide + an N10-formyltetrahydrofolate→N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + H+ + a tetrahydrofolate (EC 2.1.2.2)
BT0704 +1.8
BT2883 +0.2
BT3360 +0.1
Phosphoribosylformylglycinamidine synthase:
N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + ATP + L-glutamine + H2O→2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + ADP + L-glutamate + H+ + phosphate (EC 6.3.5.3)
BT1733 +3.9
Phosphoribosylformylglycinamidine cyclo-ligase:
2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + ATP→5-amino-1-(5-phospho-β-D-ribosyl)imidazole + ADP + H+ + phosphate (EC 6.3.3.1)
BT4211 +1.9

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information