MetaCyc Pathway: glycine betaine degradation I in Bacteroides thetaiotaomicron VPI-5482

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Reactions and Genes BHIS with Trimethoprim 0.00625 mM
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Betaine--homocysteine S-methyltransferase:
glycine betaine + L-homocysteine→N,N-dimethylglycine + L-methionine (EC 2.1.1.5)
No genes
Dimethylglycine oxidase:
N,N-dimethylglycine + dioxygen + a tetrahydrofolate→sarcosine + hydrogen peroxide + a 5,10-methylenetetrahydrofolate (EC 1.5.3.10)
No genes
sarcosine + dioxygen + a tetrahydrofolate→glycine + hydrogen peroxide + a 5,10-methylenetetrahydrofolate (EC 1.5.3.24)
No genes
Sarcosine oxidase:
sarcosine + dioxygen + H2O→glycine + formaldehyde + hydrogen peroxide (EC 1.5.3.1)
No genes
Glycine hydroxymethyltransferase (in reverse):
glycine + a 5,10-methylenetetrahydrofolate + H2O→L-serine + a tetrahydrofolate (EC 2.1.2.1)
BT0738 +0.5
L-serine ammonia-lyase:
L-serine→2-aminoprop-2-enoate + H2O (EC 4.3.1.17)
BT4678 -1.7
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
BT1492 -0.1
BT4678 -1.7
2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
BT1336 -0.5
BT1492 -0.1
BT4678 -1.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information