MetaCyc Pathway: 2-methylcitrate cycle I in Xanthomonas campestris pv. campestris strain 8004

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Reactions and Genes Citric Acid 16.67 mM (C)
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Propionate--CoA ligase:
propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)
Xcc-8004.5157.1 +1.1
2-methylcitrate synthase:
propanoyl-CoA + oxaloacetate + H2O→(2S,3S)-2-methylcitrate + coenzyme A + H+ (EC 2.3.3.5)
Xcc-8004.3980.1 +3.0
2-methylcitrate dehydratase:
(2S,3S)-2-methylcitrate→cis-2-methylaconitate + H2O (EC 4.2.1.79)
Xcc-8004.3979.1 -1.6
2-methylisocitrate dehydratase (in reverse):
cis-2-methylaconitate + H2O→(2R,3S)-2-methylisocitrate (EC 4.2.1.99)
Xcc-8004.2891.1 N.D.
Xcc-8004.2894.1 -1.0
Xcc-8004.3979.1 -1.6
Methylisocitrate lyase:
(2R,3S)-2-methylisocitrate→pyruvate + succinate (EC 4.1.3.30)
Xcc-8004.3981.1 -1.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information