MetaCyc Pathway: L-homomethionine biosynthesis in Xanthomonas campestris pv. campestris strain 8004

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Reactions and Genes D-Fructose 16.67 mM (C)
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L-methionine + a 2-oxo carboxylate→4-(methylsulfanyl)-2-oxobutanoate + a proteinogenic amino acid (EC 2.6.1.88)
Xcc-8004.2348.1 -1.2
4-(methylsulfanyl)-2-oxobutanoate + acetyl-CoA + H2O→2-[(2'-methylsulfanyl)ethyl]malate + coenzyme A + H+ (EC 2.3.3.17)
No genes
2-[(2'-methylsulfanyl)ethyl]malate→2-[(2'-methylsulfanyl)ethyl]maleate + H2O (EC 4.2.1.170)
No genes
2-[(2'-methylsulfanyl)ethyl]maleate + H2O→3-[(2'-methylsulfanyl)ethyl]malate (EC 4.2.1.170)
No genes
3-[(2'-methylsulfanyl)ethyl]malate + NAD+→2-[2-(methylsulfanyl)ethyl]-3-oxobutanedioate + NADH + H+
No genes
2-[2-(methylsulfanyl)ethyl]-3-oxobutanedioate + H+→5-(methylsulfanyl)-2-oxopentanoate + CO2 (spontaneous)
No genes
5-(methylsulfanyl)-2-oxopentanoate + a proteinogenic amino acid→L-homomethionine + a 2-oxo carboxylate
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information